Based on the search results, Jesus did have siblings:
1. The Gospels of Mark and Matthew specifically name four brothers of Jesus: James, Joseph (or Joses), Simon, and Judas (or Jude)[1][3][4].
2. The Gospels also mention that Jesus had sisters, though they are not named. There were at least two sisters[1][3].
3. These siblings were likely half-siblings, born to Mary and Joseph after Jesus' birth[3].
Regarding Jesus' ministry and his siblings:
1. During Jesus' ministry, his siblings initially did not believe in him. John 7:5 states that "his brothers did not believe in him"[1].
2. There are accounts of Jesus' mother and brothers coming to see him during his ministry, possibly to persuade him to stop his preaching activities[2].
3. After Jesus' death and resurrection, his siblings became believers. Acts 1:14 mentions that Jesus' brothers were part of the early Christian community[1][4].
4. James, one of Jesus' brothers, became a prominent leader in the early church in Jerusalem[1][4].
5. Paul mentions in 1 Corinthians 9:5 that Jesus' brothers were married and involved in ministry[4].
While there are some alternative interpretations of these relationships in certain Christian traditions, the most straightforward reading of the biblical texts suggests Jesus had biological half-siblings born to Mary and Joseph after his birth.
Sources
[1] Did Jesus Have Siblings? Names of Jesus' Brothers and Sisters https://www.bartehrman.com/did-jesus-have-siblings/
[2] Glad You Asked: Did Jesus have brothers and sisters? - U.S. Catholic https://uscatholic.org/articles/202311/glad-you-asked-did-jesus-have-brothers-and-sisters/
[3] Did Jesus have brothers and sisters (siblings)? | GotQuestions.org https://www.gotquestions.org/Jesus-siblings.html
[4] Did Jesus have any brothers, sisters or siblings? https://www.bibleinfo.com/en/questions/did-jesus-have-any-brothers-andor-sisters
[5] Did Jesus Have Siblings? Who Were His Brothers and Sisters? https://www.christianity.com/jesus/life-of-jesus/youth-and-baptism/how-many-brothers-and-sisters-did-jesus-have.html